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San Francisco 49ers vs New England Patriots; Matchup, TV Schedule

San Francisco 49ers vs New England Patriots

Here’s your NFL preview of the San Francisco 49ers vs New England Patriots for September 29th, 24. Both teams enter the matchup at 1-2 and are looking to start a winning streak during week 4 of the NFL regular season. You can check out the overview, odds, and TV schedule for the game below. 

San Francisco 49ers vs New England Patriots Preview

When I break this game down in this NFL week 4 matchup, New England is an automatic under play all year when the total is 40+ and Jacoby Brissett is the quarterback. The Patriots have a solid, playoff-type defense. Their offense leaves a lot to be desired, with absolutely no explosive playmakers. They want to rely on Rhamondre Stevenson on the ground as much as possible. Jacoby Brissett will not throw downfield, but what’s even better is that he does not make mistakes. Brissett protects the ball, forcing opponents to go the full length of the field against their solid defense, which chews up the clock.

The 49ers can be explosive, but without left tackle Trent Williams, this team is limited. Williams is questionable, Deebo Samuel is also questionable, and McCaffrey is still out. The 49ers are still fine with Mason at running back and Mr. Jauan Jennings picking up the slack at wide receiver. Tight end George Kittle also remains questionable. Brock Purdy will not be taking as many shots downfield in this game. The 49ers’ defense will manhandle this Patriots offense. We will be safe even if the 49ers put up 24 points in this spot. I’m looking for a 24-3 type game, which would cover the spread of 10. The better option in this game is the under 40.5.

What is the San Francisco 49ers vs New England Patriots Spread? 

The 49ers (1-2) are -10.5 point favorites over the New England Patriots (1-2). The over/under for the game is 40.5 points. Although it’s still early, both teams are looking to not fall too far behind in their positioning in the early NFL Playoff picture

How to Watch the San Francisco 49ers vs New England Patriots on TV? 

The San Francisco 49ers vs New England Patriots game is being shown on FOX at 1:05 PM ET. For fans who live in the regional broadcast area for each team, the local FOX affiliates will show the game OTA, and you can watch on any major cable or streaming provider who carries the FOX network.

When is the 2025 NFL Postseason Schedule? 

So, 49ers fans are eager for the team to get back into the postseason and will want to check out the NFL Playoff 2025 schedule here. Patriots fans are looking for the team to win some more early games so they are relevant in the same timeframe. You can also look at a blank NFL Playoff and Superbowl bracket up here. If you are looking for the NFL schedule grid or other regular season team schedules we have those up for you to checkout the upcoming games for the 49ers, Patriots, and other teams.  

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Have been covering sports of all types for more than 18 years. March Madness is his favorite time of year before we hit the NBA and NHL playoffs. Will is a lifelong Kentucky Wildcats fan and rooted for the Bengals way back when Joe Montana dashed our hopes and dreams. Now a Padres fan as well. He covers all sports here at Sports Brackets.
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